Meet one of the diagnostic criteria for metabolic syndrome: 1)abdominal obesity (i.e.Have great compliance on medication and follow-up；.The sum score of PANSS Marder negative factor items is at least 20.Participants are required to be on stable treatment with standard-of-care medications first-generation antipsychotics will be allowed, but only in the context of no concomitant anticholinergic agents and minimal extrapyramidal symptoms and antipsychotic medication should be no more than 2.Duration of illness less than 10 years with current symptoms in a stable condition.
SCHIZOPHRENIA MEDICATION MANUAL
Male and female with aged 18 to 50 years, who meet the Diagnostic and Statistical Manual (DSM-5) diagnostic criteria for schizophrenia.The assessments will be carried out at baseline, 12th week and 24th week, including physical examination, anthropometry, blood test(blood routine, liver function, renal function, blood lipids, fasting blood glucose, and serum insulin), electrocardiogram, MRI scan( High-resolution T1-weighted Anatomical Images, Diffusion Tensor Imaging, Resting-state functional MRI and Arterial Spin Labeling) and psychiatry scales(Positive And Negative Syndrome Scale, Scale for Assessment of Negative Symptoms, Calgary Depressing Scale for Schizophrenia, Personal and Social Performance Scale, and The Systematic Assessment for Treatment Emergent Events) cognitive function will be assessed by the Measurement and Treatment Research to Improve Cognition in Schizophrenia(MATRICS) Consensus Cognitive Battery biological samples also will be collected and stored to explore related mechanisms. The information of demographic data, medical history, previous and current medication regimen, and family history regarding psychotic and metabolic diseases will be collected at baseline. Participants screened through inclusion and exclusion criteria will be randomized to metformin or placebo group (2:1). Why Should I Register and Submit Results?.
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